All Genetic Subtypes of B-cell Acute Lymphoblastic Leukemia Exhibit Increased Incidence Rates in Children with Down Syndrome
Aug 14, 2025·
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Ruu Hsu
Jeremy M. Schraw
Tania A. Desrosiers
Amanda E. Janitz
Russell S. Kirby
Eirini Nestoridi
Wendy N. Nembhard
Jason L. Salemi
Charles Shumate
Jean Paul Tanner
Mahsa M. Yazdy
Michael E. Scheurer
Karen R. Rabin
Philip J. Lupo
Abstract
In essence, this study reports that all B-cell ALL genetic subtypes—not just the previously known CRLF2-rearranged or JAK2-mutated forms—occur at higher incidence in children with Down syndrome. This broadening of scope signals the need to consider every subtype when addressing DS-associated leukemia.
Type
Publication
Leukemia
